Friday, May 19 - Saturday, May 20, 2000
Conference 2A
| Semi-Finals May 19 10:00 am and 1:00 pm |
Final May 20 10:00 am |
2A State Champion |
| Region Champion Collinsville (23-8) |
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| vs | Alto 6-4 vs |
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| Region Champion Alto (30-6-1) |
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| 2A State Champion: Troy 2-1 |
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| Region Champion Coahoma (26-7) |
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| vs | Troy 3-2 (9) | |
| Region Champion Troy (19-8) |
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Conference 3A
Semi-Finals 5:00 pm and 8:00 pm |
Final May 20 2:00 pm |
3A State Champion |
| Region Champion Devine (28-1) |
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| vs | Devine 1-0 vs |
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| Region Champion Bowie (23-4) |
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| 3A State Champion: Kennedale 1-0 |
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| Region Champion La Grange (28-2) |
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| vs | Kennedale 1-0 | |
| Region Champion Kennedale (24-6-1) |
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Conference 4A
| Semi-Finals May 19 10:00 am and 1:00 pm |
Final May 20 5:00 pm |
4A State Champion |
| Region Champion Weatherford (32-0) |
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| vs | Weatherford 6-0 vs |
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| Region Champion Texarkana Texas (23-13-1) |
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| 4A State Champion: Weatherford 8-3 |
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| Region Champion Gregory-Portland (31-2-1) |
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| vs | Brenham 2-1 (8) | |
| Region Champion Brenham (27-14) |
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Conference 5A
| Semi-Finals May 19 5:00 pm and 8:00 pm |
Final May 20 8:00 pm |
5A State Champion |
| Region Champion South Grand Prairie (29-2) |
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| vs | Bryan 3-1 vs |
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| Region Champion Bryan (30-3) |
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| 5A State Champion: Freeport Brazoswood 1-0 (15) |
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| Region Champion Freeport Brazoswood (35-0) |
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| vs | Freeport Brazoswood 4-0 | |
| Region Champion San Antonio O'Connor (24-5) |
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UIL Softball All-Tournament Teams and Most Valuable Players
as selected by the media
| Conference 2A | |||
| Pitcher | Megan Brown | So. | Troy |
| Catcher | Stefanie Easter | Jr. | Troy |
| 1B | Hannah Snow | So. | Troy |
| 2B | Laresa King | Sr. | Alto |
| 3B | Brittany Thacker | So. | Alto |
| SS | Lauren Arthur | Jr. | Troy |
| OF | Lori Wolf | Sr. | Troy |
| OF | Kati Sturrock | So. | Alto |
| OF | Brandi Hart | Jr. | Coahoma |
| Utility | Katy Pearman | So. | Alto |
| Conference 3A | |||
| Pitcher | Joy Davis | Fr. | Devine |
| Catcher | Krista Baade | Fr. | Kennedale |
| 1B | Jessie Beard | Jr. | Kennedale |
| 2B | Lanessa Glover | Jr. | Weatherford |
| 3B | D'Anna Logos | Fr. | Kennedale |
| SS | Dee Dee Kirkpatrick | Sr. | Kennedale |
| OF | Susie Waddell | Jr. | Devine |
| OF | Ashlee Taylor | So. | Kennedale |
| OF | Megan Munsch | So. | La Grange |
| Utility | Jenna Deweber | So. | Bowie |
| Conference 4A | |||
| Pitcher | Carrie Walker | Sr. | Weatherford |
| Catcher | Kristin Gunter | So. | Brenham |
| 1B | Lauren Eckermann | Fr. | Brenham |
| 2B | Lanessa Glover | Jr. | Weatherford |
| 3B | Lacie Newson | Sr. | Weatherford |
| SS | Lyndee Davis | Jr. | Texarkana Texas |
| OF | Courtney Francis | Fr. | Weatherford |
| OF | Christy Cortez | Jr. | Gregory-Portland |
| OF | Kelly Majewski | Jr. | Brenham |
| Utility | Robin Landau | Sr. | Brenham |
| Conference 5A | |||
| Pitcher | Nicole Neuerburg | Sr. | Freeport Brazoswood |
| Catcher | Morgan Anderson | Sr. | Freeport Brazoswood |
| 1B | Kathryn Haschke | Sr. | Freeport Brazoswood |
| 2B | April Luce | Sr. | Freeport Brazoswood |
| 3B | Erin Lindsey | Jr. | Freeport Brazoswood |
| SS | Lyndsey Bond | Sr. | Bryan |
| OF | Beth Lebow | Sr. | Bryan |
| OF | Candace Damian | Sr. | Freeport Brazoswood |
| OF | Lynne Tousek | Jr. | Freeport Brazoswood |
| Utility | Rachel Werner | Jr. | Bryan |